THE PATHOLOGICAL MECHANISMS OF OBESITY-RELATED GLOMERULOPATHY: A REVIEW ARTICLE




Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor

BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival.When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of Closed Loop Sensor RAS, resulting in melanoma-like cancer.Over the years, small molecules targeting BRAFV600E have been discovered to be very effective

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